Dwarkesh Pharmaceuticals Private Limited

TYPICAL USAGE:Gastric ulcer, gastro-esophageal reflux disease,zollinger-ellison syndrome.

MECHANISM OF ACTION:Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.

TYPICAL USAGE: Duodenal ulcer. Gastric ulcer. Reflux oesophagitis. Prophylaxis of NSAID associated peptic ulcer. Zollinger-ellison syndrome and other hypersecretory states.

MECHANISM OF ACTION: Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+,K+ )- ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose- related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

TYPICAL USAGE:Duodenal and gastric ulcers, reflux or ulcerative oesophagitis. Zollinger-Ellison syndrome. NSAID-induced ulcers.

MECHANISM OF ACTION:Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, omeprazole blocks the final step in acid production thus reducing gastric acidity.

TYPICAL USAGE:Benign duodenal and gastric ulcer, Reflux oesophagitis,Acid peptic disease.

MECHANISM OF ACTION:Ranitidine blocks histamine H2-receptors in the stomach and prevents histamine-mediated gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated factor secretion or serum gastrin.