Dwarkesh Pharmaceuticals Private Limited

TYPICAL USAGE: Ear pain, fever, headache, malaise, migraine, mild to moderate pain, pain, post-vaccine reaction, short-bowel syndrome.

MECHANISM OF ACTION: Paracetamol is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Paracetamol indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. paracetamol is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. The antipyretic properties of paracetamol are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.

Drotaverine

TYPICAL USAGE: As an Antispasmodic. Useful in Cholangitis, cholecystitis, cholecytolithiasis, cystitis, nephrolithiasis, papilitis, smooth muscle spasm, stone formation, ureterolithiasis, urolithiasis, vesical tenesmus.

Paracetamol

TYPICAL USAGE: Ear pain, fever, headache, malaise, migraine, mild to moderate pain, pain, post-vaccine reaction, short-bowel syndrome.