|Each uncoated tablet contains :-|
|Allopurinol IP||300 mg|
TYPICAL USAGE:Chronic gout. Secondary hyperuricaemia due to cancer, chemotherapy, radiation and thiazides or drugs, prevention of uric acid nephropathy. Calcium renal lithiasis.
MECHANISM OF ACTION:Allopurinol and its active metabolite, oxypurinol, inhibits the enzyme xanthine oxidase,blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid. Elevated concentrations of oxypurine and oxypurine inhibition of xanthine oxidase through negative feedback leads to decrease in the concentrations of uric acid in the serum and urine. Allopurinol also facilitates the incorporation of hypoxanthine and xanthine into DNA and RNA, leading to a feedback inhibition of de novo purin synthesis and a decrease in serum uric acid concentrations as a result of an increase in nucleotide concentration.