TYPICAL USAGE: Folate-deficient. Megaloblastic anaemia. Prophylaxis of megaloblastic anemia in pregnancy. Prophylaxis of neural tube defect in pregnancy. Malabsorption syndromes. Antiepileptic therapy.
Mechanism Of Action:Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.
TYPICAL USAGE: used for the treatment of Nausea And Vomiting During Pregnancy.